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Osteoprotegerin and inflammation Volume 13, numéro 2, June 2002

Auteurs
Groupe de Recherches en Immunopathologie et Immunointervention, Faculté de Médecine Léonard-de-Vinci, 74, rue Marcel-Cachin, 93017 Bobigny Cedex, France.
  • Page(s) : 144-53
  • Année de parution : 2002

The receptor activator of NF-kappaB (RANK), RANK ligand (RANKL) and osteoprotegerin (OPG) has well established regulatory effects on bone metabolism. Links with the immune system are less known, but it seems to play a major role in modulating the immune system. ROLE IN BONE RESORPTION RANK is a membrane-spanning 616-amino acid polypeptide that comprises two regions, an extracellular N-terminal region that binds to the ligand and [...]