European Cytokine Network
MENUOsteoprotegerin and inflammation Volume 13, numéro 2, June 2002
Illustrations
N. Saidenberg Kermanac'h, Natacha Bessis, M. Cohen-Solal, M.C. De Vernejoul, Marie-Christophe Boissier
Groupe de Recherches en Immunopathologie et Immunointervention, Faculté de Médecine Léonard-de-Vinci, 74, rue Marcel-Cachin, 93017 Bobigny Cedex, France.
- Page(s) : 144-53
- Année de parution : 2002
The receptor activator of NF-kappaB (RANK), RANK ligand (RANKL) and osteoprotegerin (OPG) has well established regulatory effects on bone metabolism. Links with the immune system are less known, but it seems to play a major role in modulating the immune system. ROLE IN BONE RESORPTION RANK is a membrane-spanning 616-amino acid polypeptide that comprises two regions, an extracellular N-terminal region that binds to the ligand and [...]