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European Cytokine Network

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Molecular cloning and sequencing of the rat interleukin-12 p40 gene Volume 9, numéro 1, March 1998

Auteurs
  • Mots-clés : rat, interleukin-12 p40, promoter region, cDNA.
  • Page(s) : 69-73
  • Année de parution : 1998

INTRODUCTION IL-12 was originally isolated from a transformed B cell line [1], but was shown by ex vivo studies to be mainly produced by cells of the monocyte/macrophage lineage [2, 3]. More recent studies showed that other cell types, such as dendritic cells [4] and neutrophils [5], can synthesize this cytokine. Bioactive IL-12 was identified as a disulfide-linked heterodimer, composed of a heavy chain of 40 kDa (p40) [...]