European Cytokine Network
MENUMinimal tumor necrosis factor receptor binding protein: optimum biological activity of a truncated p55 soluble tumor necrosis factor receptor-IgG fusion protein. Volume 9, numéro 3, September 1998
Illustrations
Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, England
- Mots-clés : p55 TNF receptor, IgG chimeras, TNF binding.
- Page(s) : 255-62
- Année de parution : 1998
INTRODUCTION The pleiotropic cytokine, tumour necrosis factor-alpha (TNF-alpha), produced primarily by activated macrophages, is intimately involved in many immune and inflammatory responses including septic shock, cachexia, and rheumatoid arthritis (RA) [1-5]. TNF interacts with two high affinity cell surface receptors, which also bind the structurally related cytokine, lymphotoxin (LT) [6]. Two human soluble TNF binding [...]