John Libbey Eurotext

European Cytokine Network

Induction and large-scale expansion of CD8+ tumor specific cytotoxic T lymphocytes from peripheral blood lymphocytes by in vitro stimulation with CD80-transfected autologous melanoma cells. Volume 10, numéro 3, September 1999

Auteurs
Dept. of Hematology & Oncology, Univ. of Regensburg, Franz-Joseph-Strauss-Allee, 11, D-93042 Regensburg, Allemagne
  • Page(s) : 329-36
  • Année de parution : 1999

INTRODUCTION The existence of MHC-restricted cytotoxic T lymphocytes (CTL) with specificity for tumor-associated antigens has been demonstrated in melanoma patients. Numerous T cell epitopes of melanoma cells have been identified, and several genes encoding the respective proteins have been cloned [1]. Furthermore, tumor-specific CTL have been directly implicated in spontaneous regression of malignant melanoma lesions [2]. [...]