- Auteur(s) : A. Mackensen, S. Wittnebel, H. Veelken, C. Noppen, G.C. Spagnoli, A. Lindermann.
, Dept. of Hematology & Oncology, Univ. of Regensburg, Franz-Joseph-Strauss-Allee, 11, D-93042 Regensburg, Allemagne
- Page(s) : 329-36
- Année de parution : 1999
The existence of MHC-restricted cytotoxic T lymphocytes (CTL) with specificity
for tumor-associated antigens has been demonstrated in melanoma patients.
Numerous T cell epitopes of melanoma cells have been identified, and several
genes encoding the respective proteins have been cloned . Furthermore,
tumor-specific CTL have been directly implicated in spontaneous regression
of malignant melanoma lesions [2...