John Libbey Eurotext

European Cytokine Network

Induction and large-scale expansion of CD8+ tumor specific cytotoxic T lymphocytes from peripheral blood lymphocytes by in vitro stimulation with CD80-transfected autologous melanoma cells. Volume 10, numéro 3, September 1999


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INTRODUCTION The existence of MHC-restricted cytotoxic T lymphocytes (CTL) with specificity for tumor-associated antigens has been demonstrated in melanoma patients. Numerous T cell epitopes of melanoma cells have been identified, and several genes encoding the respective proteins have been cloned [1]. Furthermore, tumor-specific CTL have been directly implicated in spontaneous regression of malignant melanoma lesions [2...