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Functional epitope mapping of human interleukin-1 b y surface plasmon resonance Volume 8, numéro 2, June 1997

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INTRODUCTION IL-1 is a family of related proteins representing a prototypic, multifunctional cytokine. Among its multiple functions in virtually every cell type, IL-1 is one of the major mediators of host defense reactions against invasion, acting as a stimulator of the immune response mechanisms and as an initiator of inflammation-related defensive events [1, 2]. The high inflammatory activity of IL-1 leads to the need for [...]