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Evaluation of tumor necrosis factor alpha production in ex vivo short term culture whole blood from women with polycystic ovary syndrome Volume 13, numéro 4, December 2002

Auteurs
Seccion Endocrinologia, Hospital Clinico de la U. de Chile, Santos Dumont 999, Independencia, Santiago, Chile.
  • Page(s) : 419-24
  • Année de parution : 2003

Introduction Tumor necrosis factor alpha (TNFa) is one of the most pleiotropic cytokines in mammals and, among its wide array of biological functions, effects on regulation of ovarian function have been described [1, 2]. Thus, chronic anovulation, oligo or amenorrhea, infertility, hyperandrogenism, obesity, insulin resistance and higher TNF-a serum levels have been detected in women affected by polycystic ovary syndrome (PCOS), one of the [...]