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Cytokines in Gaucher’s disease. Volume 10, numéro 2, June 1999

Auteurs
Oncology Department, Hadassah University Hospital, Jerusalem, Israel.
  • Page(s) : 205-10
  • Année de parution : 1999

INTRODUCTION Gaucher's disease (GD), inherited as an autosomal recessive trait, is the most prevalent sphingolipid storage disorder. The metabolic defect of unsufficient glucocerebrosidase activity is due to mutations within the gene encoding the lysosomal enzyme, glucocerebrosidase [1], resulting in accumulation of glucocerebroside within the cells of the monocyte-macrophage system and hence, involvement of the spleen, liver [...]