- Auteur(s) : Tsung-Hsien Chuang, Richard J. Ulevitch
, Department of Immunology, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA 92037 USA.
- Page(s) : 372-8
- Année de parution : 2000
The importance of members of the Toll family of proteins
in innate immune responses to microbial pathogens is now well appreciated
as a result of studies in diverse organisms from Drosophila to
man [1, 2]. In Drosophila the Toll (dToll) gene encodes
a type-1 transmembrane receptor with an extracellular domain consisting
multiple leucine-rich repeats (LRRs), and a cytoplasmic domain exhibiting
structural and functional similarities...