John Libbey Eurotext

European Cytokine Network

Cloning and characterization of a sub-family of human Toll-like receptors: hTLR7, hTLR8 and hTLR9 Volume 11, numéro 3, September 2000

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  • Auteur(s) : Tsung-Hsien Chuang, Richard J. Ulevitch , Department of Immunology, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA 92037 USA.
  • Page(s) : 372-8
  • Année de parution : 2000

INTRODUCTION The importance of members of the Toll family of proteins in innate immune responses to microbial pathogens is now well appreciated as a result of studies in diverse organisms from Drosophila to man [1, 2]. In Drosophila the Toll (dToll) gene encodes a type-1 transmembrane receptor with an extracellular domain consisting multiple leucine-rich repeats (LRRs), and a cytoplasmic domain exhibiting structural and functional similarities...