- Auteur(s) : J. Hulkkonen, P. Laippala, M. Hurne
, M.D., Department of Microbiology and Immunology, University of Tampere Medical School, POB 607,
FIN-33101, Tampere, Finland.
- Page(s) : 251-5
- Année de parution : 2000
The inflammatory reaction in infectious and autoimmune diseases is regulated
by a delicate balance between the pro-inflammatory and anti-inflammatory
cytokines. The IL-1 gene complex contains the genes for IL-1alpha, IL-1beta
and IL-1Ra, of which the first two are strong inducers of inflammation,
while IL-1Ra binds to the IL-1 receptors with high affinity without activating
the cell, thus being an effective antagonist (for...