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European Cytokine Network

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Gene transfer-mediated expression of physiological numbers of the type II decoy receptor in a myelomonocytic cellular context dampens the response to interleukin-1 Volume 8, numéro 3, September 1997

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INTRODUCTION IL-1 consists of two polypeptide mediators (IL-1alpha and IL-1ß) which are among the most potent and multifunctional cell activators. The spectrum of action of IL-1 includes cells of hematopoietic origin, from immature precursors to differentiated leukocytes, vessel wall elements and cells of mesenchymal, nervous and epithelial origin [1, 2]. The production and action of IL-1 are regulated by multiple control [...]