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Circulating interleukin-6 type cytokines in patients with systemic lupus erythematosus Volume 8, numéro 3, September 1997

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INTRODUCTION Interleukin-6 (IL-6) is a pleiotropic, immunomodulatory cytokine produced by a variety of cell types, including fibroblasts, endothelial cells, monocytes and both benign and malignant lymphocytes of B and T cell origin [1, 2]. It has a number of biological functions including B-cells stimulation and differentiation into antibody-producing cells. Studies with recombinant IL-6 or antibodies against IL-6 have shown [...]