John Libbey Eurotext

European Journal of Dermatology


MicroRNA in skin diseases Volume 27, numéro 4, July-August 2017

Figure 1

Psoriasis-associated microRNAs.

Figure 2

Implication of miR-155 in atopic dermatitis: miR-155 acts as a negative regulator of cytotoxic T lymphocyte-associated antigen 4 (CTLA4), thereby increasing inflammation in affected skin. Moreover, over-expression of miR-155 in dermal cells results in activation, proliferation, and differentiation of CD4(+) T cells.

Figure 3

Regulation of melanoma progression by miR-17 and miR-18b. Up-regulation of miR-17 inhibits expression of ETS variant 1 protein (ETV1), which affects melanoma cell motility and migration. MiR-18b under-expression, caused by methylation of the gene, activates migratory and invasive features of melanoma cells.