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European Cytokine Network

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Interleukin-10 – mediated T cell apoptosis during the T helpertype 2 cytokine response in murine Schistosoma man-soni parasite infection Volume 8, numéro 2, June 1997

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INTRODUCTION Differentiated CD4+ T helper (Th) cells have been shown in mice and humans to segregate into two major functional subsets, based on their cytokine secretion pattern; Th1 cells secrete IL-2 and IFN-gamma, promote macrophage activation, and induce cell-mediated immunity and delayed-type hypersensitivity reactions; Th2 cells secrete IL-4, IL-5 and IL-10, favor optimal activation of B cells to secrete antibody, in [...]