JLE

European Journal of Dermatology

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Expression of estrogen-related receptor beta (ERRβ) in human skin Volume 20, numéro 6, November-December 2010

Auteurs
Laboratoire des Substituts Cutanés, CNRS UPR-412, Hôpital Edouard Herriot 5 Place d'Arsonval, 69437 Lyon, France, BASF Beauty Care Solutions, 32 rue Saint Jean de Dieu, 69007 Lyon, France, Université de Lyon, Lyon, F-69008; Université Lyon1, ISPB, Laboratoire de Dermopharmacie et Cosmétologie, Lyon, F-69008, France ; LAGEP, CNRS, UMR 5007, 43 Bd du 11 Novembre 1918, Villeurbanne, F-69622, France, IFR128 BioSciences Lyon-Gerland; Institut de Biologie et Chimie des Protéines; UMR 5086; CNRS; Univ. Lyon1; Lyon, France

Skin is a non classical target tissue for estrogens, whose biological and mechanical properties are affected by the hormonal deprivation occurring at the menopause. Estrogen-related receptors (ERR), closely related to the estrogen receptors (ER), constitute a subfamily of orphan receptors, interfering with ER-mediated signalling pathways. The expression of ERRβ has been detected in only a few adult tissues so far, such as the prostate and the inner ear. Here, we demonstrate the expression of ERRβ in normal human skin. ERRβ was detected in human epidermis, in both keratinocytes and Langerhans cells, by immunohistochemistry. These results were validated on freshly extracted epidermal cells and on monolayer-cultured keratinocytes by RT-PCR and western blotting (WB), suggesting the implication of ERRβ in skin immunity and endocrine effects.