European Cytokine Network
MENUNegative regulation of oncostatin M (OM) signalling by suppressor of cytokine signalling-3 (SOCS-3). Volume 12, numéro 2, June 2001
Illustrations
Unité INSERM 463, Institut de Biologie, CHR de Nantes, 9, quai Moncousu, 44095 Nantes Cedex 01, France.
- Page(s) : 309-15
- Année de parution : 2001
INTRODUCTION OSM was originally identified by its ability to inhibit the growth of human A375 melanoma cells [1, 2]. OSM can exert opposite biological effects depending on cell types. For example, OSM stimulates the proliferation of Kaposi's sarcoma [3], muscle cells [4] and endothelial cells [5] while it inhibits the growth of melanoma [1, 2], breast carcinoma [6] and lung carcinoma [7]. OSM is a cytokine structurally and functionally [...]