JLE

European Cytokine Network

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Interleukin-1-mediated febrile responses in mice and inter-leukin-1 beta activation of NFB in mouse primary astrocytes, involves the interleukin-1 receptor accessory protein Volume 9, numéro 2, June 1998

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INTRODUCTION Interleukin-1 (IL-1) is a pleiotrophic cytokine mainly synthesised by activated macrophages and lymphocytes upon immune stimulation. IL-1 has profound proinflammatory actions and is thought to be a key cytokine in orchestrating the host's cytokine cascade upon injury and infection (for review, see Dinarello, 1996 [1]).The IL-1 family of ligands consist of at least three proteins, the agonists IL-1alpha and IL-1ß [...]