John Libbey Eurotext

Virologie

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Novel antiviral compounds and combination therapy for influenza viruses Volume 23, numéro 6, Novembre-Décembre 2019

Illustrations

  • Figure 1
Auteurs
1 Université Laval,
CHUL, RC-709,
Québec, Canada, G1V 4G2
2 Virpath,
CIRI Inserm U1111,
CNRS, ENS de Lyon,
Université Claude-Bernard,
69372 Lyon,
France
* Correspondence

Influenza viruses A and B are members of the Orthomyxoviridae family that includes segmented RNA viruses of negative polarity. During its replicative cycle (figure 1), the viral hemagglutinin (HA) binds to sialic acids receptors on the host cell surface. Subsequently, the entry process occurs by endocytosis or micropinocytosis. Endosomal acidification activates the HA resulting in the fusion of the viral envelope and endosomal membrane. The decapsidation process then releases the nucleic acids into [...]