La présence du variant Pi*Z de l’α1-antitrypsine augmente le risque de cirrhose alcoolique et de cirrhose « métabolique »
Volume 26, numéro 5, Mai 2019
[4]Morin T., Martin J.P., Feldmann G., Rueff B., Benhamou J.P., Ropartz C. Heterozygous alpha 1-antitrypsin deficiency and cirrhosis in adults, a fortuitous association. Lancet. 1975;i:250-251.
[5]Romeo S., Kozlitina J., Xing C. Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease. Nat Genet. 2008;40:1461-1465.
[6]Salameh H., Raff E., Erwin A. PNPLA3 gene polymorphism is associated with predisposition to and severity of alcoholic liver disease. Am J Gastroenterol. 2015;110:846-856.
[7]Stickel F., Buch S., Lau K. Genetic variation in the gene is associated with alcoholic liver injury in caucasians. Hepatology. 2011;53:86-95. PNPLA3
[8]Meroni M, Longo M, Rametta R, Dongiovanni P. Genetic and epigenetic modifiers of alcoholic liver disease. Int J Mol Sci 2018 ; 19 : 3857-78.