Figure 3
Deregulation of the epigenetic control of gene expression in hairy cell leukaemia and identification of new therapeutic targets. Modification, methylation and acetylation occur at histone tails and control DNA compaction and thus transcriptional activity. The proteins responsible for these modifications, EZH2, BET or histone deacetylase (HDAC), can be targeted by various drugs shown in red. Proteins shown in red with an asterisk are frequently deregulated in HCL and/or HCL-v.