John Libbey Eurotext

Epileptic Disorders

The Educational Journal of the

Why the TimeToStop trial failed to recruit: a survey on antiepileptic drug withdrawal after paediatric epilepsy surgery Volume 20, numéro 5, October 2018

Illustrations

  • Figure 1
  • Figure 2
  • Figure 3

Tableaux

Auteurs
Kees P.J. Braun on behalf of the TimeToStop trial group 1 *
1 Department of Child Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht and Utrecht University, Member of the European Reference Network EpiCARE, Utrecht, the Netherlands
2 Biomedical MR Imaging and Spectroscopy Group, Center for Image Sciences, University Medical Center Utrecht and Utrecht University, Utrecht, the Netherlands
3 Paediatric Clinical Epileptology, Sleep Disorders and Functional Neurology Department, University Hospitals of Lyon (HCL), Member of the European Reference Network EpiCARE, Lyon Neurosciences Research Centre, Lyon, France
4 Universitat de Barcelona, Hospital San Juan de Deu Epilepsy Unit, Member of the European Reference Network EpiCARE, Barcelona, Spain
5 Clinical Neurosciences, UCL-Great Ormond Street Institute of Child Health, Great Ormond Street Hospital for Children NHS Foundation Trust, Coordination of the European Reference Network EpiCARE, London & Young Epilepsy Lingfield, UK
6 Unité de Neuropédiatrie, Hôpitaux Universitaries de Genève, Genève, Switzerland
7 Neuropediatrics, University Children's Hospital Zürich, Zürich, Switzerland
* Correspondence: Kees PJ Braun Department of Child Neurology, Brain Center, Rudolf Magnus, University Medical Center Utrecht, 3508 AB, Utrecht, Netherlands
  • Mots-clés : anticonvulsive medication, discontinuation, epileptologist, children, epilepsy surgery
  • DOI : 10.1684/epd.2018.1003
  • Page(s) : 374-85
  • Année de parution : 2018

Aims

Following the results of the multicentre European retrospective “TimeToStop” cohort study, we initiated a randomised trial to determine cognitive benefits of early postoperative antiepileptic drug withdrawal. Unfortunately, the trial failed to recruit and was terminated, as almost all parents preferred early drug withdrawal. The objectives of the current survey were to obtain insight into current practices regarding drug withdrawal after paediatric epilepsy surgery among epileptologists, and better understand the reasons for difficulties in recruitment.