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Epileptic Disorders

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Piracetam and levetiracetam: close structural similarities but different pharmacological and clinical profiles Volume 2, numéro 2, Juin 2000

Auteurs
Centre St-Paul, 300, boulevard St-Marguerite, 13009 Marseille, France.
  • Page(s) : 99-105
  • Année de parution : 2000

Slight and subtle differences in molecular configuration can cause marked changes in pharmacological activity as, for example, the structural similarity of male and female sex hormones. Such is also the case with the structurally related molecules PIR and LEV which have different and distinct pharmacological profiles. Although many pyrrolidone derivatives exist, only a few are have been developed: PIR, aniracetam and pramiracetam (figure 1). Of these, [...]