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Pharmacological monitoring of antiepileptic drugs in epilepsy patients on haemodialysis Volume 22, numéro 1, February 2020

TEST YOURSELF

(1) What were the clinical features of epilepsy patients undergoing haemodialysis?

 

(2) What proportion of LEV, VPA, CBZ, PHT, CLB and PB is reduced by haemodialysis?

 

(3) Which AED is commonly used for epilepsy patients on haemodialysis?

 

 

 

 

 

 

 

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Answers

(1) The majority of epilepsy patients on haemodialysis had cerebrovascular diseases and diabetes, and most patients had AED-responsive focal epilepsy.

 

(2) The clearance rate during HD is 0.65 for LEV, 0.33 for VPA, 0.41 for CBZ, 0.29 for PHT, 0.24 for CLB, and 0.63 for PB.

 

(3) LEV was the most commonly used AED in this study with a high therapeutic effect, but may require supplementary doses after haemodialysis.

 

 

 

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