Figure 1
fMRI activations and lateralization indices (LI) for Patient 1 and controls. (A) Picture naming fMRI activation maps of controls, Patient 1, and Patient 1 versus controls (statistical differences). Activation maps were presented at p < 0.05-corrected thresholds. (B) Lateralization indices (LI) for Patient 1 and the control group, based on t values (iterations). LI was computed on the basis of the number of activated voxels in the frontal region, reflecting the hemispheric specialization for language; the LI-tool implemented in SPM was used. In each graph. the red area indicates positive LI (from +0.2 to +1) and left hemispheric specialization, whereas the blue area indicates negative LI (from -0.2 to -1) and right hemispheric specialization; the green area pertains to the LI between -0.2 and +0.2 and indicates bilateral representation of language. The calculation of LI was based on the method described by Seghier (Baciu et al., 2005; Seghier, 2008).