JLE

Epileptic Disorders

MENU

Infantile epileptic encephalopathy with a hyperkinetic movement disorder and hand stereotypies associated with a novel SCN1A mutation Volume 16, numéro 2, June 2014

Figure 1

Brain MRI of patient. (A) A transverse T2-weighted image of the cerebrum at the age of 3 months shows slight atrophy in the left hemisphere. (B) A transverse T2-weighted image of the cerebrum at the age of 3 years and 8 months shows diffuse cortical atrophy in addition to white matter, particularly in the frontal lobe, a thin corpus callosum, and impaired myelination, particularly in the frontal lobe. (C) A transverse T2-weighted image of the cerebrum at the age of 6 years and 6 months shows progressive atrophy of the cortex, and a thin corpus callosum. Myelination of the hemispheric white matter is shown to have commenced gradually, especially in the occipital lobe.