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Antiepileptic drugs: evolution of our knowledge and changes in drug trials Volume 21, numéro 4, August 2019

Figure 1

Increase in number of antiepileptic drugs (AEDs) during the period 1857 (year of introduction of bromide) to 1969. All compounds listed reached the market. The year of introduction refers to the first clinical trial for epilepsy. Modified from Friedlander (1986), with permission from the publisher.