John Libbey Eurotext

Epileptic Disorders

The Educational Journal of the

Absence of increased blood decanoic acid levels in children with epilepsy treated with classic ketogenic diet Volume 21, numéro 4, August 2019

Tableaux

Auteurs
1 Université Paris Diderot, Sorbonne Paris Cité, INSERM UMR1141, Paris
2 AP-HP, Hôpital Robert Debré, Service de Neurologie Pédiatrique, Paris
3 AP-HP, Hôpital Robert Debré, Service de Biochimie, Paris, France
* Correspondence: Stéphane Auvin Service de neurologie pédiatrique et des maladies métaboliques, CHU Hôpital Robert Debré, 48, boulevard Sérurier, 75935 Paris cedex 19, France
  • Mots-clés : decanoic acid, epilepsy, fatty acid, ketogenic diet
  • DOI : 10.1684/epd.2019.1079
  • Page(s) : 366-9
  • Année de parution : 2019

Aim

Recently, decanoic acid (C10), a medium-chain fatty acid, was shown to be a direct inhibitor of the AMPA receptor. Accordingly, C10 has been suggested as a potential anticonvulsant factor in the ketogenic diet (KD) or the medium-chain triglyceride KD. Here, we tested whether C10 serum levels correlate with the response to KD in five children (1.5 ± 0.6 years of age) with epilepsy.