Epileptic Disorders
MENUAbsence of increased blood decanoic acid levels in children with epilepsy treated with classic ketogenic diet Volume 21, numéro 4, August 2019
Auteurs
Aim
1 Université Paris Diderot, Sorbonne Paris Cité, INSERM UMR1141, Paris
2 AP-HP, Hôpital Robert Debré, Service de Neurologie Pédiatrique, Paris
3 AP-HP, Hôpital Robert Debré, Service de Biochimie, Paris, France
* Correspondence: Stéphane Auvin
Service de neurologie pédiatrique et des maladies métaboliques,
CHU Hôpital Robert Debré,
48, boulevard Sérurier,
75935 Paris cedex 19, France
- Mots-clés : decanoic acid, epilepsy, fatty acid, ketogenic diet
- DOI : 10.1684/epd.2019.1079
- Page(s) : 366-9
- Année de parution : 2019
Recently, decanoic acid (C10), a medium-chain fatty acid, was shown to be a direct inhibitor of the AMPA receptor. Accordingly, C10 has been suggested as a potential anticonvulsant factor in the ketogenic diet (KD) or the medium-chain triglyceride KD. Here, we tested whether C10 serum levels correlate with the response to KD in five children (1.5 ± 0.6 years of age) with epilepsy.