Epileptic Disorders


A comprehensive clinico-pathological and genetic evaluation of bottom-of-sulcus focal cortical dysplasia in patients with difficult-to-localize focal epilepsy Volume 21, numéro 1, February 2019


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1 Epilepsy Center, Cleveland Clinic, Cleveland, Ohio, USA
2 Neuropathological Institute, University Hospitals Erlangen, Erlangen
3 Cologne Center for Genomics, University of Cologne, Cologne, Germany
4 Stanley Center for Psychiatric Research, Broad Institute of Harvard & MIT, Cambridge, Massachusetts, USA
* Correspondence: Zhong Ying S51 Epilepsy Center, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195, USA


We comprehensively studied the clinical presentation, stereo-EEG and MRI findings, histopathological diagnosis, and brain somatic mutations in a retrospective series of drug-resistant patients with difficult-to-localize epilepsy due to focal cortical dysplasia at the bottom of a sulcus (BOS-FCD).