John Libbey Eurotext

European Journal of Dermatology

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Transglutaminase 3 is expressed in basal cell carcinoma of the skin Volume 29, numéro 5, September-October 2019

Illustrations

  • Figure 1
  • Figure 2
  • Figure 3
  • Figure 4
Auteurs
1 Department of Experimental Medicine, TOR, University of Rome “Tor Vergata”, 00133 Rome, Italy
2 Istituto Dermopatico dell’Immacolata-IRCCS, 00163 Rome, Italy
3 Department of Dermatology, University of Rome “Tor Vergata”, 00133 Rome, Italy
4 MRC-Toxicology Unit, University of Cambridge, UK
* Reprints
  • Mots-clés : basal cell carcinoma, keratinocytes, melanoma, skin cancer, squamous cell carcinoma, transglutaminase 3
  • DOI : 10.1684/ejd.2019.3636
  • Page(s) : 477-83
  • Année de parution : 2019

Background

Transglutaminase 3 (TG3) belongs to a family of Ca2+-dependent enzymes which catalyse protein crosslinking. TG3 is important for proper development of the skin and hair shaft, and knock-out mice for the Tgm3 gene are sensitive to UVB-induced photodamage due to aberrations in cornified envelope formation. Loss of TG3 is reported in head and neck and oesophageal squamous cell carcinoma, yet, its expression in skin cancer has not been studied.