John Libbey Eurotext

European Journal of Dermatology

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Successful hybrid grafting of autologous cultured epidermis carrying a revertant mutation and split mesh skin in a patient with recessive dystrophic epidermolysis bullosa Volume 32, numéro 3, May-June 2022

Illustrations

  • Figure 1.
Auteurs
1 Department of Dermatology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
2 Department of Stem Cell Therapy Science, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
3 Japan Tissue Engineering Co., Ltd., Kamagori, Aichi, Japan
4 StemRIM Institute of Regeneration-Inducing Medicine, Osaka University, Suita, Osaka, Japan

We herein report successful re-epithelization of refractory ulcers using an autologous cultured epidermal sheet carrying a revertant mutation and concomitant mesh skin grafting in a patient with recessive dystrophic epidermolysis bullosa (RDEB).A 41-year-old man diagnosed with RDEB had been suffering from erythematous hypertrophic scars and ulcers, especially on the extremities and upper back to nape (figure 1A). Repeated scratching due to severe itching, resistant to any medication, resulted in [...]