John Libbey Eurotext

European Journal of Dermatology


Resident's corner. sQuiz: Generalized lesions resembling water droplets after treatment with idarubicin and all-trans retinoic acid Article à paraître


  • Figure 1
Unidad de Gestión Clínica Dermatología y Venereología, Hospital Universitario Puerta del Mar, Cádiz, Spain

A 67-year-old woman with acute promyelocytic leukaemia began treatment with idarubicin at 20 mg on Day 1, 3 and 5, combined with all-trans retinoic acid (ATRA) at 40 mg every 12 hours. On Day 11, she presented with many clear superficial blisters, without inflammation, 1-2 mm in diameter, diffusely affecting the trunk and arms. The blisters were fragile and appeared as water droplets (figures 1A, B). Dermoscopy showed clear circular features with ring enhancement that resembled soap bubbles (figure [...]