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European Journal of Dermatology

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Pathological nerve patterns in human basal cell carcinoma Volume 31, numéro 3, May-June 2021

Figure 1

Pattern 1 showing a nerve fibre repositioning (arrow) due to the mechanical pressure of a tumour mass (TM). Green: PGP 9.5 staining of nerve fibres; red: type IV collagen staining of connective tissue (blood vessels). D: dermis. Bar: 100 μm.

Figure 2

Pattern 2 showing a nerve fibre tangle (small arrows) in the dermis (D), not far from a tumour mass (TM). Green: PGP 9.5 staining of nerve fibres; red: type IV collagen staining of connective tissue (blood vessels). E: epidermis. D: dermis. Bar: 100 μm.

Figure 3

A nerve fibre bundle (small arrows) in the dermis (D), from the apex of a sebaceous gland (SG) to the epidermis (E). Green: PGP 9.5 staining of nerve fibres; red: type IV collagen staining of connective tissue (mainly blood vessels). Bar: 100 μm.

Figure 4

Pattern 3 showing clear hyperinnervation of the epidermis with an increased density of epidermal nerve fibres (arrowheads). Green: PGP 9.5 staining of nerve fibres; red: type IV collagen staining of connective tissue (blood vessels). E: epidermis. D: dermis. Bar: 100 μm.