Department of Pediatrics, University Hospital Würzburg, Würzburg, Germany
Department of Internal Medicine II, Rheumatology and Clinical Immunology, University Hospital Würzburg, Würzburg, Germany
Institute of Human Genetics, University of Würzburg, Würzburg, Germany
Department of Dermatology, Venereology and Allergology, University Hospital Würzburg, Würzburg, Germany
Institute of Pathology, University of Würzburg, and Comprehensive Cancer Center Mainfranken, Würzburg, Germany
College of Health and Life Sciences, Hamad Bin Khalifa University, Education City, Doha, Qatar
Systemic sclerosis (SSc) is a predominantly T-cell-mediated autoimmune disorder with a characteristic sequence of Th1 and Th2 inflammation resulting in fibrosis. The contribution of differentiated memory T-cell subpopulations and methylation of CpG regions of Th1- or Th2-specific transcription factor genes on the inflammatory cytokine signature in SSc is not well understood.