John Libbey Eurotext

European Journal of Dermatology


Memory CD4+ T cells lacking expression of CCR7 promote pro-inflammatory cytokine production in patients with diffuse cutaneous systemic sclerosis Volume 29, numéro 5, September-October 2019


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1 Department of Pediatrics, University Hospital Würzburg, Würzburg, Germany
2 Department of Internal Medicine II, Rheumatology and Clinical Immunology, University Hospital Würzburg, Würzburg, Germany
3 Institute of Human Genetics, University of Würzburg, Würzburg, Germany
4 Department of Dermatology, Venereology and Allergology, University Hospital Würzburg, Würzburg, Germany
5 Institute of Pathology, University of Würzburg, and Comprehensive Cancer Center Mainfranken, Würzburg, Germany
6 College of Health and Life Sciences, Hamad Bin Khalifa University, Education City, Doha, Qatar
* Reprints


Systemic sclerosis (SSc) is a predominantly T-cell-mediated autoimmune disorder with a characteristic sequence of Th1 and Th2 inflammation resulting in fibrosis. The contribution of differentiated memory T-cell subpopulations and methylation of CpG regions of Th1- or Th2-specific transcription factor genes on the inflammatory cytokine signature in SSc is not well understood.