Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo,
Department of Dermatology, Kindai University Faculty of Medicine, Osaka-Sayama,
Department of Dermatology, Acne Clinical and Research Center, Meiwa Hospital, Nishinomiya,
Department of Pathology II, Kansai Medical University, Hirakata, Japan
These authors contributed equally
- Mots-clés : epidermal nevus, nevus depigmentosus, melanosome, epidermal differentiation, keratin, filaggrin
- DOI : 10.1684/ejd.2018.3496
Background: Nevus is a hamartoma or malformation of one or more skin components, resulting in aberrant differentiation of the cell lineage(s) mostly during developmental stages. Although multiple lineages may be involved in a nevus, the combination of melanocyte and keratinocyte abnormalities has been rarely discussed. Objectives. To present two cases of congenital nevi with hypomelanosis and superficial fine scales. Materials & Methods: Skin specimens of the patients were analysed by immunohistochemistry and electron microscopy. Results: Morphological and immunohistochemical studies indicated aberrant epidermal differentiation in the lesional skin specimens. Electron microscopy showed defective melanosome maturation in the melanocytes of the nevi samples. Conclusion: These results demonstrate that both epidermal and melanocytic lineages can concomitantly contribute to the formation of a nevus lesion.