John Libbey Eurotext

European Journal of Dermatology


A case of severe immediate type reaction to macrogol and polysorbate 60 after intravaginal drug application Volume 29, numéro 3, May-June 2019


1 Department of Dermatology, Venereology and Allergology, University of Leipzig,
2 LICA - Leipzig Comprehensive Allergy Center, Leipzig, Germany

Polyethylene glycols (PEG; pharmacologically called macrogols [C2nH4n+2On+1]) are water-soluble polymers used in pharmacy and cosmetics as carriers. PEG may be occult and an underestimated inducer of immediate type reactions [1, 2]. We report a 26-year-old non-atopic woman who presented with generalized urticaria, pruritus, and dyspnoea which developed 15 minutes after using a vaginal suppository containing lactic acid, macrogol 1500/6000, and sodium lactate (Vagisan® Zäpfchen) as well as a vaginal [...]