Lebanese University, Faculty of Sciences II, Department of Life and Earth Sciences, Beirut, Lebanon
CHU of Poitiers, University of Poitiers, Laboratoire inflammation, tissus épithéliaux et cytokines (LITEC), EA4331, Poitiers, France
Saint Joseph University, Faculty of Medicine, Medical Genetics Unit, Beirut, Lebanon
Institut Jérôme Lejeune, Paris, France
Correspondence: Department of Life and Earth Sciences, Faculty of Sciences II, Lebanese University, Box 90656, Jdeidet El Metn, Fanar, Lebanon.
- Mots-clés : ex vivo, FMF, IL-1β, RAC1, oxidative stress
- DOI : 10.1684/ecn.2018.0416
- Page(s) : 127-35
- Année de parution : 2018
Familial Mediterranean fever (FMF) is a recessively inherited autoinflammatory disorder. The caspase-1-dependent cytokine, IL-1β, plays an important role in FMF pathogenesis, and RAC1 protein has been recently involved in IL-1β secretion. This study aims to investigate RAC1 expression and role in IL-1β and caspase-1 production and oxidative stress generation in FMF.