John Libbey Eurotext

European Cytokine Network

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RAC1 expression and role in IL-1β production and oxidative stress generation in familial Mediterranean fever (FMF) patients Volume 29, numéro 4, October-November-December 2018

Illustrations

  • Figure 1
  • Figure 2
  • Figure 3
  • Figure 4
  • Figure 5
  • Figure 6
Auteurs
1 Lebanese University, Faculty of Sciences II, Department of Life and Earth Sciences, Beirut, Lebanon
2 CHU of Poitiers, University of Poitiers, Laboratoire inflammation, tissus épithéliaux et cytokines (LITEC), EA4331, Poitiers, France
3 Saint Joseph University, Faculty of Medicine, Medical Genetics Unit, Beirut, Lebanon
4 Institut Jérôme Lejeune, Paris, France
* Correspondence: Department of Life and Earth Sciences, Faculty of Sciences II, Lebanese University, Box 90656, Jdeidet El Metn, Fanar, Lebanon.
  • Mots-clés : ex vivo, FMF, IL-1β, RAC1, oxidative stress
  • DOI : 10.1684/ecn.2018.0416
  • Page(s) : 127-35
  • Année de parution : 2018

Objectives

Familial Mediterranean fever (FMF) is a recessively inherited autoinflammatory disorder. The caspase-1-dependent cytokine, IL-1β, plays an important role in FMF pathogenesis, and RAC1 protein has been recently involved in IL-1β secretion. This study aims to investigate RAC1 expression and role in IL-1β and caspase-1 production and oxidative stress generation in FMF.