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IL-10 induces TGF-β secretion, TGF-β receptor II upregulation, and IgA secretion in B cells Volume 30, numéro 3, September 2019

Illustrations


  • Figure 1

  • Figure 2

  • Figure 3
Auteurs
1 Iran University of Medical Sciences, School of Medicine, Department of Immunology, Tehran, Iran
2 Iran University of Medical Sciences, Institute of Immunology and Infectious Diseases, Immunology Research Center (IRC), Tehran, Iran
3 Tehran University of Medical Sciences, Pediatrics Center of Excellence, Children's Medical Center, Research Center for Immunodeficiencies, Tehran, Iran
4 Tarbiat Modares University, Faculty of Medical Sciences, Department of Immunology, Tehran, Iran
5 Alborz University of Medical Sciences, Non-Communicable Diseases Research Center, Karaj, Iran
6 Karolinska Institute at Karolinska University Hospital Huddinge, Department of Laboratory Medicine, Division of Clinical Immunology, Stockholm, Sweden
* Correspondence: Mehdi Shekarabi, Iran University of Medical Sciences, School of Medicine, Department of Immunology, Shahid Hemmat Highway, Tehran, 1449614535, Iran.
* Correspondence: Asghar Aghamohammadi, Children's Medical Center Hospital, 62 Qarib St., Keshavarz Blvd., Tehran 14194, Iran.

Background

Interleukin-10 (IL-10) is a pleiotropic cytokine, which has both regulatory and stimulatory effects on different immune cell types. Different studies have reported the importance of IL-10 and Transforming growth factor-beta (TGF-β) in the regulation of B cell class switching the production of immunoglobulin A (IgA); however, the underlying mechanisms remain to be fully elucidated. The objective of this study was to investigate the TGF-β response during B stimulation of human B cells by IL-10.