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Dexmedetomidine alleviates hepatic injury via the inhibition of oxidative stress and activation of the Nrf2/HO-1 signaling pathway Volume 30, numéro 3, September 2019

Illustrations


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Auteurs
Department of Anesthesia (Clinical Research Center for Anesthesiology of ERAS in Hunan Province), Hunan provincial people's hospital (First Affiliated Hospital of Hunan Normal University), Changsha 410005, P.R.China
* Correspondence: Dr. Bing-Bing Pan, Department of Anesthesia (Clinical Research Center for Anesthesiology of ERAS in Hunan Province), Hunan provincial people's hospital (First Affiliated Hospital of Hunan Normal University), No.61, West Jiefang Road, Furong District, Changsha 410005, Hunan Province, P.R.China: B-B. Pan

Background

Dexmedetomidine (Dex), frequently used as an effective sedative, was reported to play a critical role in the protection of multiple organs. However, its underlying mechanism of a putative protective effect on ischemia/reperfusion (I/R)-induced liver injury is still unclear.