Bulletin du Cancer
MENUImplication of HIC1 (Hypermethylated In Cancer 1) in the DNA damage response Volume 96, numéro 11, novembre 2009
Illustrations
CNRS-UMR 8161, Institut de Biologie de Lille, Université de Lille-Nord de France, Institut Pasteur de Lille, IFR 142, 1, rue Calmette, BP447, 59017, Lille Cedex, France
- Mots-clés : HIC1, p53, SIRT1, E2F1, DNA damage
- DOI : 10.1684/bdc.2009.0959
- Page(s) : 10066-72
- Année de parution : 2009
HIC1 (Hypermethylated In Cancer 1) is a tumor suppressor gene which is epigenetically inactivated in many human cancers. HIC1 encodes a transcriptional repressor comprising an N-terminal BTB/POZ domain and a C-terminal DNA binding domain containing five Krüppel-like C 2H 2 zinc fingers. To date, few HIC1 target genes are known and the regulation of HIC1 activity is not fully deciphered. However, a growing list of studies, summarized in this review, strongly suggest that HIC1 plays a central role in the DNA damage response through the establishment of several complex regulatory loops involving HIC1, p53, SIRT1 and E2F1.