Sang Thrombose Vaisseaux


C-reactive protein and cardiovascular prevention Volume 14, issue 3, Mars 2002


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laboratoire de biochimie cardiovasculaire, hôpital européen Georges-Pompidou, 20, rue Leblanc, 75015 Paris.
  • Page(s) : 172-8
  • Published in: 2002

Cardiovascular diseases are the major cause of death in industrialized nations. It is now universally recognized that inflammation plays a pivotal role in the pathogenesis of atherosclerosis from initial leukocyte recruitement to eventual rupture of the unstable atherosclerotic plaque. The lesions of atherosclerosis represent a series of highly specific cellular and molecular responses. In an increasing number of studies, elevated plasma levels of several markers of the inflammatory cascade have been shown to predict future risk of cardiovascular events. High sensitivity CRP (hs-CRP) has emerged as the most powerful inflammatory independent marker of these risks. The addition of CRP screening to traditional lipid testing or cardiospecific markers has the potential to identify individuals at high risk for future cardiovascular events who may benefit from targeted preventives interventions. The European and American societies of cardiology give it a potential important role in the evaluation of the overall cardiovascular risk so much in primary that secondary prevention.