Cahiers Santé Médecine Thérapeutique


Can lipid profile predict subclinical hypercortisolism in adrenal incidentalomas? Volume 31, issue 3-4, Mai-Août 2022


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1 CHU Hassan II, service d’endocrinologie, diabétologie, maladies métaboliques et nutrition, Fès, Maroc
2 Université Sidi Mohamed Ben Abdellah, faculté de médecine et de pharmacie, Fès, Maroc
3 Laboratoire d' épidémiologie et de recherche en sciences de la santé
* Tirés à part : F.Z. Lahmamssi

Subclinical cortisol adenoma (SCIA) is a benign tumour that secretes cortisol autonomously, but is not sufficient to cause overt clinical and biological Cushing's syndrome, but can suppress the corticotropic axis to varying degrees. The aim of our study is to determine whether lipid disturbance can be a marker of subclinical cortisol secretion. Materials and methods: Case-control study comparing patients followed for subclinical cushing's syndrome (SCIC) (group B) to patients followed for non-functional adrenal adenomas (group A) at the Endocrinology and Metabolic Disease Department at the Hassan II University Hospital in Fez for three years. Results: Group B had a higher cortisol after minute braking test than group A [(5 ± 2.6 μg/dL vs. 1.02 ± 0.38 μg/dL) (P < 0.05). It was found that 48% of patients in group B had a metabolic syndrome vs. 29.62% in group A (p = 0.013) and that lipid disturbances were significantly correlated with CICS (56.2 vs. 18.4%) (P<0.05). Conclusion: Our study shows that lipid balance can predict cortisol secretion in subclinical cortisolic adenomas.