Centre de recherche de l’Institut universitaire de gériatrie de Montréal et département de psychologie, Université de Montréal, 4565 Queen Mary, Montréal H3W 1W5, Québec, Canada
- Key words: reserve, cognitive training, cognitive aging, Alzheimer's disease
- DOI : 10.1684/nrp.2016.0394
- Page(s) : 245-52
- Published in: 2016
The reserve concept was proposed to account for the interindividual differences between the degree of brain damage and its clinical expression. Reserve was found to be modulated by environmental factors such as the level of education and the practice of cognitively stimulating activities during life. An important issue is to understand the neurobiological mechanisms underlying reserve capacity in order to promote interventions that would strengthen it. Results from studies on the neurobiological mechanisms involved in different types of cognitive training and their similarities with those of reserve lead us to hypothesize that reserve can be built later in life through cognitive interventions. We will discuss the advantage of having a high level of reserve and the opportunity to build one at a later time, during the phase of aging.