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Néphrologie & Thérapeutique

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Chronic kidney disease consecutive to chemotherapy for chondroblastic osteosarcoma: A report on 6 pediatric cases Volume 17, issue 7, Décembre 2021

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1 IntroductionOsteosarcoma is one of the most frequent malignant neoplasm in children [1]. In the literature, it is described that chondroblastic types represent 20–25% of osteosarcomas [2,3]. First-line therapy is based on chemotherapy and surgery. Several reports demonstrated that ifosfamide, an alkylating agent, has a beneficial effect as first-line therapy for localized or metastatic tumors [1], and as second-line treatment in case of relapse [1]. It is more and more used in children since it [...]