Néphrologie & Thérapeutique


APOL1 risk genotype in Europe: Data in patients with focal segmental glomerulosclerosis and after renal transplantation Volume 15, supplement 1, Avril 2019


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1 IntroductionApolipoprotein L1 (APOL1)-associated nephropathies are a spectrum of related non-diabetic kidney diseases strongly associated with G1 and G2 coding risk variants in populations with African ancestry. It has been observed that African-Americans have a fourfold increased risk for end-stage renal disease. Two studies identified a locus on chromosome 22 associated with non-diabetic end-stage renal disease, focal segmental glomerulosclerosis, human immunodeficiency virus (HIV)-associated [...]