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Médecine de la Reproduction

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Embryo vitrification and cumulative success rates: is the debate closed between transfers at cleavage or blastocyst stage? Volume 21, issue 4, Octobre-Novembre-Décembre 2019

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Author
Institut de médecine de la reproduction, laboratoire Alphabio, clinique Bouchard, Marseille, France
* Tirés à part

Several physiological arguments tend to assume that transfers of blastocysts are more efficient than transfer of embryos at cleavage stage. The present review of the literature shows that while cycles with blastocyst transfer are more often followed by a pregnancy after fresh transfer, they are however more often associated with a lack of transfer and embryo vitrification, a technic that allows to get additional pregnancies. In total, there is no convincing difference in terms of cumulative pregnancy rate or live birth rate per initial cycle. It seems however that blastocyst transfers allow to get a pregnancy more rapidly. In a qualitative point of view, blastocyst transfers seem to be more often associated with prematurity and perinatal mortality but seem to be less associated with ectopic pregnancy.

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