JLE

Médecine de la Reproduction

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The endometrial receptivity array test (ERA) for personalization of embryo transfer (pET) Volume 15, issue 3, Juillet-Août-Septembre 2013

Authors
Fundación Instituto Valenciano de Infertilidad (FIVI), and Instituto Universitario IVI/ Incliva, Valencia University. Parc Cientific Universitat de Valéncia. C/Catedrático Agustín Escardino n̊9, Edificio 3, 46980 Paterna (Valencia), Spain, Iviomics S.L. Parc Cientific Universitat de Valéncia. C/Catedrático Agustín Escardino n̊9, Edificio 3, 46980 Paterna (Valencia), Spain

The endometrium is a factor that has been neglected in the research efforts to improve implantation rates. Here, we summarize previous studies on biomarkers of receptivity and review our publications on the development of the ERA test. This test is based in a customized gene expression microarray, that contains 238 genes differentially expressed in the receptive endometrium, coupled to a computational predictor, trained with a set of menstrual cycle phase controlled samples, that is able to diagnose whether the endometrium of a patient sampled at the assumed WOI is receptive or not, regardless of its histological appearance. The analysis of the transcriptomic profile allows us to suggest a personalized WOI that can be validated with a second ERA test and used for personalized embryo transfer. Accuracy and reproducibility of the test have been analyzed and its clinical application has been tested on recurrent implantation failure patients.