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Médecine de la Reproduction

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Prolonged culture: results for embryo co-culture on human endometrial cells Volume 14, issue 4, Octobre-Novembre-Décembre 2012

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Authors
Laboratoire Glasgow, Unité de Fécondation in vitro, Clinique Pasteur, 34, rue du moulin à Poudre, 29200 Brest, France, Centre AMP Saint Roch, 43, rue du Faubourg St-Jaumes, 34090 Montpellier, France

Results in IVF pregnancy rates are still perfectible. Prolonged culture to the blastocyst stage proves to be a very interesting alternative to improve such results. Indeed, the blastocyst, ultimate cell stage before implantation, allows us a better selection of embryos suitable for nidation. In addition, by obtaining blastocysts, we can put into practice the transfer of a single embryo (SET : Single Embryo Transfer) to reduce the not wished effect of AMP that is multiple pregnancies. The use of Co-Culture, instead of sequential environments, gives us a much better performance not only on the pregnancy rate expressed as a percentage of clinical pregnancies, but their scalability and the baby take home rate. The use of endometrial cells from the patient (Endocell trial from Genevrier Labs) or from a donor as a support of this culture is very promising.