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Médecine de la Reproduction

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Are there reliable criteria for predicting the chances of pregnancy in recipients of egg donation? What makes a “good donor”? French multicentre retrospective study conducted by GEDO (Groupe d’Etudes pour le Don d’Ovocytes) Volume 26, issue 1, janvier-février-mars 2024

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Authors
1 Sorbonne Université, unité d’AMP clinique, hôpital Tenon, AP-HP, Paris, France
2 Centre d’AMP, Site CMCO, HUS, Strasbourg, France
3 Service de gynécologie, obstétrique et médecine de la reproduction et préservation de la fertilité, hôpital Foch, Suresnes, France
4 Département d’assistance médicale à la procréation et préservation de la fertilité, polyclinique Pau Pyrénées, Pau, France
* Tirés à part : E. Mathieu d’Argent

With the aim of improving oocyte donation practices in France, a French multicentre retrospective study was conducted by the (Groupe d’ Etudes pour le Don d’Ovocytes). The purpose of the study was to identify criteria for predicting chances of pregnancy in patients receiving medically assisted reproduction with oocyte donation. Twelve French oocyte donation centres retrospectively collected data from 1 186 oocyte donation cycles carried out between 2019 and 2022. The various characteristics of donors and stimulation cycles were analysed regarding the first objective: rate of achieving at least one pregnancy after egg donation IVF cycle. The mean age of donors at the time of oocyte retrieval was 31.5 ± 4.51 years [18-38]; their mean BMI was 23.6 ± 4.10 kg/m2; 21% of donors were smokers. With regard to ovarian reserve parameters, the mean AMH level was 3.46 ± 2.51 ng/mL, the mean CFA was 21.4 ± 12.0. The stimulation protocols used were the antagonist protocol for 85 % of donors, the agonist protocol for 3.1 %, and the progestin protocol (PPOS) for 12 %. The protocol was not documented for 15.4 % of cycles. Twenty-four per cent of donors had received a prescription for corifollitropine alfa. Fifteen per cent of the donors in the study had self-preserved part of the oocytes collected. A study of these parameters with regard to achieving at least one pregnancy in the recipients shows that donors aged between 23 and 29 have the best probability of achieving at least one pregnancy in the recipient(s). In multivariate analysis, the main parameter associated with the chances of pregnancy in recipients was the number of mature oocytes donated. The number of oocytes required to obtain at least one pregnancy was 10.6. Further analysis is required to refine donation strategies with the aim of improving pregnancy rates in recipients.