John Libbey Eurotext

Médecine de la Reproduction


Action of antimüllerian hormone in the hypothalamus and pituitary gland and its pathophysiological role in polycystic ovary syndrome Volume 24, issue 2, Avril-Mai-Juin 2022


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Université Lille, Inserm, CHU Lille, Lille neuroscience & cognition, UMR-S 1172, Lille, France <>
* Tirés à part : M. Peigné

Research on the physiological actions of anti-Mullerian hormone (AMH) has rapidly expanded from its classical role in male sex differentiation to the regulation of ovarian function. Over the past 10 years, the idea that AMH acts exclusively in the gonads has evolved with the publication of exciting studies highlighting actions of AMH along the hypothalamicpituitary-gonadal axis (HPG). In this review, we will focus on these findings reporting novel actions of AMH on the HPG axis and discuss their potential impact and importance for better understanding human reproductive disorders related to alterations in the development of neuroendocrine circuits regulating fertility. Finally, we will summarize recent preclinical studies suggesting that elevated AMH levels may potentially be a contributing factor to the central pathophysiology of PCOS.