Innovations & Thérapeutiques en Oncologie
MENUMacrophages associated with tumours: new therapeutic targets Volume 4, issue 5-6, September-December 2018
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Service de médecine interne
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- Key words: macrophages, tumor microenvironment, immunotherapy
- DOI : 10.1684/ito.2018.0140
- Page(s) : 235-9
- Published in: 2018
Macrophages are versatile immune cells that harbour multiple functions in order to maintain homeostasis. The tumour microenvironment with its metabolites alters the status of macrophages, which then become pro-tumoural and therefore protect cancer cells from being attacked by cytotoxic T cells. Additionally, cancer cells secrete different chemokines that attract immature macrophages, which also have a higher protumoural potential. Recently, many different molecules have been developed to target macrophages, and as a result, these may have the potential to convert protumoural macrophages into antitumoural macrophages. These efforts should result in a better antitumoural response when combined with chemotherapy or immune checkpoint inhibitors.
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