Hépato-Gastro & Oncologie Digestive
MENUSleep disorders, immunity and inflammatory bowel diseases Volume 29, issue 7, September 2022
- Key words: Crohn’s disease, UC, sleep disturbance, immunity
- DOI : 10.1684/hpg.2022.2422
- Page(s) : 783-91
- Published in: 2022
Sleep disorders affect 47% to 82% of Inflammatory Bowel Disease (IBD) patients and are associated with both the inflammatory activity and the clinical course of the disease. Disease activity and the presence of associated anxiety disorders are the main risk factors for sleep disturbance in IBD patients. However, almost 50% of patients in remission maintain poor sleep quality, suggesting a close relationship between IBD and sleep disturbances that may contribute to the fatigue observed in most of IBD patients. Several studies report a bidirectional link between sleep disturbance and inflammation. In Crohn’s disease, the presence of sleep disorders is an early marker of subclinical inflammation and in patients in remission, poor sleep quality is associated with the risk of relapse at 6 months. Sleep disturbances are important contributors to functional disability in IBD, and their detection and management may improve patient quality of life. The impact of the management of sleep disorder on IBD activity remains to be investigated.